Causes,Symptoms In Asthma
It’s a clinical condition of occurring reversible airway obstruction due to airway hyper-sensitivity and is categorized by cough, difficulty in breathing, chest tightness and presence of a whistle like sound while breathing. Airway hyper-sensitivity is triggered by various factors which lead to acute obstruction of the airway.
What causes Asthma?
The causes of asthma is poorly defined and mainly due to combination of environmental and genetic factors.
Some theories suggest that asthma in early childhood is caused by decreased infections in early life which prevent the formation of proper immunity and lead to development of airway hyper-sensitivity.
Warm, humid, centrally heated homes favor multiplication of house dust mites and this may contribute to childhood asthma. Having a pet at home may also lead to development of asthma.
Deficiency of dietary components like Vitamin A, C, E, milk fat, and selenium may lead to development of asthma. Obesity may also act as a factor in it’s development.
What happens in Asthma?
In a situation when an allergen is inhaled 2 thinks occur in airway track. First one occur immediately leading to obstruction of the track. This allergen rapidly interacts with mucosal mast cells by an IgE-dependent mechanism, resulting in the release of mediators such as histamine and the cysteinyl leukotrienes with resulting constriction of the track. This is followed by a late response in which inflammation occurs in the track. This late response occurs about 5-6 hours later to the initial attack.
With the progression of the disease, remodelling of the airway occurs, leading to fibrosis of the airway wall, fixed narrowing of the airway and a reduced response to airway dilator medication.
Symptoms of Asthma?
- Difficulty in breathing
- Chest tightness
- Whistling sound on breathing
The above symptoms are terrible in the mornings but sometimes in poorly controlled and managed asthma, the symptoms tend to wake the person up from sleep at night making it all difficult. Mostly, cough is the main symptom of initial identification of asthma.